Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Jian Xie; Timothy Owen; Ke Xia; Ajay Vikram Singh; Emiley Tou; Lingyun Li; Brigitte Arduini; Hongmin Li; Leo Q. Wan; Brian Callahan; Chunyu Wang

doi:10.1074/jbc.M114.623264

Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Jian Xie, Timothy Owen, Ke Xia, Ajay Vikram Singh, Emiley Tou, Lingyun Li, Brigitte Arduini, Hongmin Li, Leo Q. Wan, Brian Callahan, Chunyu Wang

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

Original language	English (US)
Pages (from-to)	11591-11600
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.623264
State	Published - May 1 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation",

abstract = "Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.",

author = "Jian Xie and Timothy Owen and Ke Xia and Singh, {Ajay Vikram} and Emiley Tou and Lingyun Li and Brigitte Arduini and Hongmin Li and Wan, {Leo Q.} and Brian Callahan and Chunyu Wang",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = may,

day = "1",

doi = "10.1074/jbc.M114.623264",

language = "English (US)",

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T1 - Zinc inhibits hedgehog autoprocessing

T2 - Linking zinc deficiency with hedgehog activation

AU - Xie, Jian

AU - Owen, Timothy

AU - Xia, Ke

AU - Singh, Ajay Vikram

AU - Tou, Emiley

AU - Li, Lingyun

AU - Arduini, Brigitte

AU - Li, Hongmin

AU - Wan, Leo Q.

AU - Callahan, Brian

AU - Wang, Chunyu

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

AB - Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

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SN - 0021-9258

VL - 290

SP - 11591

EP - 11600

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Abstract

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