Abstract
Three new δ-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known δ-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.
Original language | English (US) |
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Pages (from-to) | 1820-1822 |
Number of pages | 3 |
Journal | Journal Of Natural Products |
Volume | 69 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2006 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry