ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

George G. Chen; Ursula P.F. Chan; Long Chuan Bai; King Yip Fung; Art Tessier; Ann K.Y. To; Juanita L. Merchant; Paul B.S. Lai

doi:10.1016/j.canlet.2009.03.024

ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

George G. Chen
, Ursula P.F. Chan
, Long Chuan Bai
, King Yip Fung
, Art Tessier
, Ann K.Y. To
, Juanita L. Merchant
, Paul B.S. Lai

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

Original language	English (US)
Pages (from-to)	52-58
Number of pages	7
Journal	Cancer Letters
Volume	283
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.03.024
State	Published - Sep 28 2009
Externally published	Yes

Keywords

Caspase-6
Cell cycle
Hepatocellular carcinoma
Proliferation
ZBP-89
p53

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2009.03.024

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@article{db3d1746f564411daac6e8f51b61d79e,

title = "ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest",

abstract = "ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.",

keywords = "Caspase-6, Cell cycle, Hepatocellular carcinoma, Proliferation, ZBP-89, p53",

author = "Chen, \{George G.\} and Chan, \{Ursula P.F.\} and Bai, \{Long Chuan\} and Fung, \{King Yip\} and Art Tessier and To, \{Ann K.Y.\} and Merchant, \{Juanita L.\} and Lai, \{Paul B.S.\}",

note = "Funding Information: This work was supported by the Research Grants Council of the Hong Kong SAR. No: CUHK4551/05 M to PBSL and GGC, and Public Heath Service Grant R01 DK-55732 to JLM. ",

year = "2009",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2009.03.024",

language = "English (US)",

volume = "283",

pages = "52--58",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

AU - Chen, George G.

AU - Chan, Ursula P.F.

AU - Bai, Long Chuan

AU - Fung, King Yip

AU - Tessier, Art

AU - To, Ann K.Y.

AU - Merchant, Juanita L.

AU - Lai, Paul B.S.

N1 - Funding Information: This work was supported by the Research Grants Council of the Hong Kong SAR. No: CUHK4551/05 M to PBSL and GGC, and Public Heath Service Grant R01 DK-55732 to JLM.

PY - 2009/9/28

Y1 - 2009/9/28

N2 - ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

AB - ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

KW - Caspase-6

KW - Cell cycle

KW - Hepatocellular carcinoma

KW - Proliferation

KW - ZBP-89

KW - p53

UR - https://www.scopus.com/pages/publications/67650383725

UR - https://www.scopus.com/pages/publications/67650383725#tab=citedBy

U2 - 10.1016/j.canlet.2009.03.024

DO - 10.1016/j.canlet.2009.03.024

M3 - Article

C2 - 19362768

AN - SCOPUS:67650383725

SN - 0304-3835

VL - 283

SP - 52

EP - 58

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

Abstract

Keywords

ASJC Scopus subject areas

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