ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

George G. Chen, Ursula P.F. Chan, Long Chuan Bai, King Yip Fung, Art Tessier, Ann K.Y. To, Juanita L. Merchant, Paul B.S. Lai

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalCancer Letters
Volume283
Issue number1
DOIs
StatePublished - Sep 28 2009
Externally publishedYes

Keywords

  • Caspase-6
  • Cell cycle
  • Hepatocellular carcinoma
  • p53
  • Proliferation
  • ZBP-89

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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