ZBP-89, a Kruppel-type zinc finger protein, inhibits cell proliferation

Monica C. Remington, Susan A. Tarlé, Babette Simon, Juanita L. Merchant

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


ZBP-89 is a Kruppel-type zinc finger transcription factor that binds to GC-rich sequences. Overexpression of this factor prevents EGF induction of the gastrin promoter; therefore, we postulated that ZBP-89 may modulate cellular proliferation. To test this hypothesis, ZBP-89 was overexpressed in immortalized (GH4) and malignant (AGS) cell lines. Growth parameters, e.g., 3H-thymidine, BrdU labeling, flow cytometry and ornithine decarboxylase promoter activity were analyzed. The results show that DNA synthesis is inhibited and progression to S phase is blocked in GH4 cells. Collectively, these studies demonstrate that ZBP-89 inhibits cellular proliferation at least in part through its ability to bind and repress ornithine deacarboxlyase promoter activity.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Aug 18 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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