TY - JOUR
T1 - Young inversion with multiple linked QTLs under selection in a hybrid zone
AU - Lee, Cheng Ruei
AU - Wang, Baosheng
AU - Mojica, Julius P.
AU - Mandáková, Terezie
AU - Prasad, Kasavajhala V.S.K.
AU - Goicoechea, Jose Luis
AU - Perera, Nadeesha
AU - Hellsten, Uffe
AU - Hundley, Hope N.
AU - Johnson, Jenifer
AU - Grimwood, Jane
AU - Barry, Kerrie
AU - Fairclough, Tephen
AU - Jenkins, Jerry W.
AU - Yu, Yeisoo
AU - Kudrna, David A
AU - Zhang, Jianwei -
AU - Talag, Jayson
AU - Golser, Wolfgang
AU - Ghattas, Kathryn
AU - Schranz, M. Eric
AU - Wing, Rod
AU - Lysak, Martin A.
AU - Schmutz, Jeremy
AU - Rokhsar, Daniel S.
AU - Mitchell-Olds, Thomas
N1 - Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - Fixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favoured alleles at multiple loci. However, it is unknown whether favoured mutations slowly accumulate on older inversions or if young inversions spread because they capture pre-existing adaptive quantitative trait loci (QTLs). By genetic mapping, chromosome painting and genome sequencing, we have identified a major inversion controlling ecologically important traits in Boechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.
AB - Fixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favoured alleles at multiple loci. However, it is unknown whether favoured mutations slowly accumulate on older inversions or if young inversions spread because they capture pre-existing adaptive quantitative trait loci (QTLs). By genetic mapping, chromosome painting and genome sequencing, we have identified a major inversion controlling ecologically important traits in Boechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.
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U2 - 10.1038/s41559-017-0119
DO - 10.1038/s41559-017-0119
M3 - Article
C2 - 28812690
AN - SCOPUS:85025125724
SN - 2397-334X
VL - 1
JO - Nature Ecology and Evolution
JF - Nature Ecology and Evolution
IS - 5
M1 - 0119
ER -