YB-1 Translational Control of Epithelial-Mesenchyme Transition

Ghassan Mouneimne, Joan S. Brugge

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations


Transitions between epithelial and mesenchmal phenotypes play critical roles in normal development and cancer progression. In this issue of Cancer Cell, Evdokimova et al. demonstrate that YB-1 regulates epithelial-mesenchyme transition (EMT) by inducing cap-independent translation of mRNAs encoding EMT-promoting factors and suppressing cap-dependent translation of mRNAs encoding growth-promoting factors.

Original languageEnglish (US)
Pages (from-to)357-359
Number of pages3
JournalCancer Cell
Issue number5
StatePublished - May 5 2009

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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