XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

Daniel R. Principe, Rui Xiong, Yangfeng Li, Thao N.D. Pham, Suneel D. Kamath, Oleksii Dubrovskyi, Kiira Ratia, Fei Huang, Jiong Zhao, Zhengnan Shen, Dinesh Thummuri, Zhou Daohong, Patrick W. Underwood, Jose Trevino, Hidayatullah G. Munshi, Gregory R.J. Thatcher, Ajay Rana

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

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  • CBP bromodomain complexed with YF2-23

    Principe, D. R. (Contributor), Xiong, R. (Contributor), Li, Y. (Contributor), Pham, T. N. D. (Contributor), Kamath, S. D. (Contributor), Dubrovskyi, O. (Contributor), Ratia, K. (Contributor), Huang, F. (Contributor), Zhao, J. (Contributor), Shen, Z. (Contributor), Thummuri, D. (Contributor), Daohong, Z. (Contributor), Underwood, P. W. (Contributor), Trevino, J. (Contributor), Munshi, H. G. (Contributor), Thatcher, G. R. J. (Contributor), Rana, A. (Contributor), Gutgesell, L. M. (Contributor), Dye, K. (Contributor), Zhao, H. (Contributor) & Tonetti, D. A. (Contributor), Protein Data Bank (PDB), Sep 1 2021

    DOI: 10.2210/pdb7JUO/pdb, https://www.wwpdb.org/pdb?id=pdb_00007juo

    Dataset