Xenopus as a model system for vertebrate heart development

Andrew S. Warkman; Paul A. Krieg

doi:10.1016/j.semcdb.2006.11.010

Xenopus as a model system for vertebrate heart development

Andrew S. Warkman, Paul A. Krieg

Cellular and Molecular Medicine

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

Original language	English (US)
Pages (from-to)	46-53
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.semcdb.2006.11.010
State	Published - Feb 2007

Keywords

Antisense oligonucleotides
Explants
Mis-expression
Promoter analysis
Transgenic animals

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2006.11.010

Cite this

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title = "Xenopus as a model system for vertebrate heart development",

abstract = "The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.",

keywords = "Antisense oligonucleotides, Explants, Mis-expression, Promoter analysis, Transgenic animals",

author = "Warkman, {Andrew S.} and Krieg, {Paul A.}",

note = "Funding Information: A.S.W. is the recipient of a Postdoctoral Fellowship Award from the American Heart Association. P.A.K. is the Allan C. Hudson and Helen Lovaas Endowed Professor of the Sarver Heart Center at the University of Arizona College of Medicine. Work in the Krieg lab is funded by the Sarver Heart Center and a National Institutes of Health research grant from the National Heart, Lung and Blood Institute (R01 HL074184).",

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AU - Krieg, Paul A.

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Y1 - 2007/2

N2 - The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

AB - The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

KW - Antisense oligonucleotides

KW - Explants

KW - Mis-expression

KW - Promoter analysis

KW - Transgenic animals

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Xenopus as a model system for vertebrate heart development

Abstract

Keywords

ASJC Scopus subject areas

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