X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance

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• Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct

  Thomaston, J. L. (Contributor), Konstantinidi, A. (Contributor), Liu, L. (Contributor), Lambrinidis, G. (Contributor), Tan, J. (Contributor), Caffrey, M. (Contributor), Wang, J. (Contributor), Degrado, W. F. (Contributor) & Kolocouris, A. (Contributor), Protein Data Bank (PDB), Jan 15 2020

  DOI: 10.2210/pdb6OUG/pdb, https://www.wwpdb.org/pdb?id=pdb_00006oug

  Dataset

• Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor

  Thomaston, J. L. (Contributor), Konstantinidi, A. (Contributor), Liu, L. (Contributor), Lambrinidis, G. (Contributor), Tan, J. (Contributor), Caffrey, M. (Contributor), Wang, J. (Contributor), Degrado, W. F. (Contributor) & Kolocouris, A. (Contributor), Protein Data Bank (PDB), Jan 15 2020

  DOI: 10.2210/pdb6NV1/pdb, https://www.wwpdb.org/pdb?id=pdb_00006nv1

  Dataset