Work-related asthma

Athena T. Jolly, Julia E. Klees, Karin A. Pacheco, Tee L. Guidotti, Howard M. Kipen, Jeremy J. Biggs, Mark H. Hyman, Bruce K. Bohnker, Matthew S. Thiese, Kurt T. Hegmann, Philip Harber

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: Summarize developed evidencebased diagnostic and treatment guidelines for work-related asthma (WRA). Methods: Comprehensive literature reviews conducted with article critiquing and grading. Guidelines developed by a multidisciplinary expert panel and peer-reviewed. Results: Evidence supports spirometric testing as an essential early test. Serial peak expiratory flow rates measurement is moderately recommended for employees diagnosed with asthma to establish work-relatedness. Bronchial provocation testing is moderately recommended. IgE and skin prick testing for specific high-molecular weight (HMW) antigens are highly recommended. IgG testing for HMW antigens, IgE testing for low-molecular weight antigens, and nitric oxide testing for diagnosis are not recommended. Removal from exposure is associated with the highest probability of improvement, but may not lead to complete recovery. Conclusion: Quality evidence supports these clinical practice recommendations. The guidelines may be useful to providers who diagnose and/or treat WRA.

Original languageEnglish (US)
Pages (from-to)e121-e129
JournalJournal of occupational and environmental medicine
Issue number10
StatePublished - 2015

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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