Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models

Philipp Gutruf; Rose T. Yin; K. Benjamin Lee; Jokubas Ausra; Jaclyn A. Brennan; Yun Qiao; Zhaoqian Xie; Roberto Peralta; Olivia Talarico; Alejandro Murillo; Sheena W. Chen; John P. Leshock; Chad R. Haney; Emily A. Waters; Changxing Zhang; Haiwen Luan; Yonggang Huang; Gregory Trachiotis; Igor R. Efimov; John A. Rogers

doi:10.1038/s41467-019-13637-w

Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models

Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov, John A. Rogers

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174 Scopus citations

Abstract

Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stability and excellent biocompatibility. Optogenetic stimulation of cardiac cycles with in-animal control and induction of heart failure through chronic pacing serve as examples of modes of operation relevant to fundamental and applied cardiovascular research and biomedical technology.

Original language	English (US)
Article number	5742
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-13637-w
State	Published - Dec 1 2019

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Gutruf, P., Yin, R. T., Lee, K. B., Ausra, J., Brennan, J. A., Qiao, Y., Xie, Z., Peralta, R., Talarico, O., Murillo, A., Chen, S. W., Leshock, J. P., Haney, C. R., Waters, E. A., Zhang, C., Luan, H., Huang, Y., Trachiotis, G., Efimov, I. R., & Rogers, J. A. (2019). Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature communications, 10(1), Article 5742. https://doi.org/10.1038/s41467-019-13637-w

Gutruf, P, Yin, RT, Lee, KB, Ausra, J, Brennan, JA, Qiao, Y, Xie, Z, Peralta, R, Talarico, O, Murillo, A, Chen, SW, Leshock, JP, Haney, CR, Waters, EA, Zhang, C, Luan, H, Huang, Y, Trachiotis, G, Efimov, IR & Rogers, JA 2019, 'Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models', Nature communications, vol. 10, no. 1, 5742. https://doi.org/10.1038/s41467-019-13637-w

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Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models

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