Wide-field phase imaging for the endoscopic detection of dysplasia and early-stage esophageal cancer

C. R.M. Fitzpatrick, G. S.D. Gordon, T. W. Sawyer, T. D. Wilkinson, S. E. Bohndiek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Esophageal cancer has a 5-year survival rate below 20%, but can be curatively resected if it is detected early. At present, poor contrast for early lesions in white light imaging leads to a high miss rate in standard-of-care endoscopic surveillance. Early lesions in the esophagus, referred to as dysplasia, are characterized by an abundance of abnormal cells with enlarged nuclei. This tissue has a different refractive index profile to healthy tissue, which results in different light scattering properties and provides a source of endogenous contrast that can be exploited for advanced endoscopic imaging. For example, point measurements of such contrast can be made with scattering spectroscopy, while optical coherence tomography generates volumetric data. However, both require specialist interpretation for diagnostic decision making. We propose combining wide-field phase imaging with existing white light endoscopy in order to provide enhanced contrast for dysplasia and early-stage cancer in an image format that is familiar to endoscopists. Wide-field phase imaging in endoscopy can be achieved using coherent illumination combined with phase retrieval algorithms. Here, we present the design and simulation of a benchtop phase imaging system that is compatible with capsule endoscopy. We have undertaken preliminary optical modelling of the phase imaging setup, including aberration correction simulations and an investigation into distinguishing between different tissue phantom scattering coefficients. As our approach is based on phase retrieval rather than interferometry, it is feasible to realize a device with low-cost components for future clinical implementation.

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy XIII
EditorsMelissa J. Suter, Guillermo J. Tearney, Thomas D. Wang
ISBN (Electronic)9781510614253
StatePublished - 2018
EventEndoscopic Microscopy XIII 2018 - San Francisco, United States
Duration: Jan 27 2018Jan 29 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherEndoscopic Microscopy XIII 2018
Country/TerritoryUnited States
CitySan Francisco


  • cancer
  • capsule endoscopy
  • dysplasia
  • early detection
  • phase retrieval

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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