Wide-field nano-scale imaging on a chip

E. McLeod, A. Ozcan

Research output: Chapter in Book/Report/Conference proceedingChapter


Wide-field imaging facilitates the detection of rare events and reduces imaging time for large-area samples. Nano-scale imaging enables the detection and enumeration of individual nanoparticles and sub-cellular bioparticles. Uniting these two capabilities in a compact and field-portable on-chip imaging platform through lensfree holographic microscopy provides deep submicron resolution with high sensitivity over fields of view in the range 10-1800mm2 - approximately 150-2700 times larger than a typical 40-215;objective field of view. High resolution is achieved via a pixel super-resolution approach, while high sensitivity is obtained via a sample preparation procedure that generates self-assembled nanolenses around individual nanoparticles and viruses. The foundations of these computational imaging approaches, along with their methodology and results, are discussed.

Original languageEnglish (US)
Title of host publicationApplications of Nanoscience in Photomedicine
PublisherElsevier Inc.
Number of pages22
ISBN (Electronic)9781908818782
ISBN (Print)9781907568671
StatePublished - Feb 3 2015
Externally publishedYes


  • Computational imaging
  • Digital holography
  • Fourier optics
  • Lensfree imaging
  • Nanolenses
  • Nanoscopy
  • On-chip imaging
  • Self-assembly
  • Wide-field microscopy

ASJC Scopus subject areas

  • General Medicine


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