TY - JOUR
T1 - Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy?
AU - Consolo, Filippo
AU - Pozzi, Loris
AU - Sferrazza, Giulia
AU - Della Valle, Patrizia
AU - D'Angelo, Armando
AU - Slepian, Marvin J.
AU - Pappalardo, Federico
N1 - Publisher Copyright:
© 2018 The Society of Thoracic Surgeons
PY - 2018/2
Y1 - 2018/2
N2 - In patients with left ventricular assist device support and aspirin allergy, the choice of effective antiplatelet strategy remains a challenge. We compared the antithrombotic effect of clopidogrel vs ticagrelor in an LVAD patient with aspirin allergy by using a modified protocol of the thrombin generation test, accounting selectively for the platelet contribution on thrombin generation. Our results demonstrate enhanced antithrombotic efficacy offered by ticagrelor. Consistent with experimental results, the patient has passed more than 300 days without thromboembolic complications. This study provides additional mechanistic rationale supporting clinical evidence and opens the perspective to identify individual poor responsiveness to drugs by specifically evaluating drug-mediated platelet function.
AB - In patients with left ventricular assist device support and aspirin allergy, the choice of effective antiplatelet strategy remains a challenge. We compared the antithrombotic effect of clopidogrel vs ticagrelor in an LVAD patient with aspirin allergy by using a modified protocol of the thrombin generation test, accounting selectively for the platelet contribution on thrombin generation. Our results demonstrate enhanced antithrombotic efficacy offered by ticagrelor. Consistent with experimental results, the patient has passed more than 300 days without thromboembolic complications. This study provides additional mechanistic rationale supporting clinical evidence and opens the perspective to identify individual poor responsiveness to drugs by specifically evaluating drug-mediated platelet function.
UR - http://www.scopus.com/inward/record.url?scp=85041361926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041361926&partnerID=8YFLogxK
U2 - 10.1016/j.athoracsur.2017.09.022
DO - 10.1016/j.athoracsur.2017.09.022
M3 - Article
C2 - 29362190
AN - SCOPUS:85041361926
SN - 0003-4975
VL - 105
SP - e47-e49
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 2
ER -