Abstract
Triazabutadienes are an understudied structural motif that have remarkable reactivity once rendered water-soluble. It is shown that these molecules readily release diazonium species in a pH-dependent manner in a series of buffer solutions with pH ranges similar to those found in cells. Upon further development, we expect that this process will be well suited to cargo-release strategies and organelle-specific bioconjugation reactions. These compounds offer one of the mildest ways of generating diazonium species in aqueous solutions.
Original language | English (US) |
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Pages (from-to) | 4051-4054 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 13 |
DOIs | |
State | Published - Mar 23 2015 |
Keywords
- diazonium salts
- kinetics
- protonation
- triazabutadienes
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)