TY - JOUR
T1 - Water solubility
T2 - A critique of the solvatochromic approach
AU - Yalkowsky, Samuel H.
AU - Pinal, Rodolfo
AU - Banerjee, Sujit
PY - 1988/1
Y1 - 1988/1
N2 - The reasoning and some of the assumptions behind the solvatochromic approach to water solubility are evaluated, particularly in relation to its claims. It is shown that the contribution of the π* term is uncertain, and that it can be dropped from the correlation without substantially affecting the degree of fit. The solvatochromic method is compared with the long‐standing relationship between solubility and the octanol‐water partition coefficient, and it is demonstrated that the latter offers a far superior route to solubility estimation.
AB - The reasoning and some of the assumptions behind the solvatochromic approach to water solubility are evaluated, particularly in relation to its claims. It is shown that the contribution of the π* term is uncertain, and that it can be dropped from the correlation without substantially affecting the degree of fit. The solvatochromic method is compared with the long‐standing relationship between solubility and the octanol‐water partition coefficient, and it is demonstrated that the latter offers a far superior route to solubility estimation.
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U2 - 10.1002/jps.2600770114
DO - 10.1002/jps.2600770114
M3 - Article
C2 - 3346826
AN - SCOPUS:0023782406
SN - 0022-3549
VL - 77
SP - 74
EP - 77
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 1
ER -