Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

Joseph L. Blackshear; Miguel Zabalgoitia; Gregory Pennock; Paul Fenster; Richard Strauss; Jonathan Halperin; Richard Asinger; Lesly A. Pearce

doi:10.1016/S0002-9149(98)00886-8

Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

Joseph L. Blackshear
, Miguel Zabalgoitia
, Gregory Pennock
, Paul Fenster
, Richard Strauss
, Jonathan Halperin
, Richard Asinger
, Lesly A. Pearce

Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Patients with atrial fibrillation and with documented oartic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

Original language	English (US)
Pages (from-to)	453-455
Number of pages	3
Journal	American Journal of Cardiology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9149(98)00886-8
State	Published - Feb 1 1999

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(98)00886-8

Cite this

@article{a24901c478d941c387f6c67cc875a11a,

title = "Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation",

abstract = "Patients with atrial fibrillation and with documented oartic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7\% (95\% confidence interval [CI] 0.1\% to 5.3\%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9\%/year; 95\% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3\%/year; 95\% CI 11 to 27; p = 0.01).",

author = "Blackshear, \{Joseph L.\} and Miguel Zabalgoitia and Gregory Pennock and Paul Fenster and Richard Strauss and Jonathan Halperin and Richard Asinger and Pearce, \{Lesly A.\}",

note = "Funding Information: This study was supported by Grants R01-NS-33551 and R01-NS-24224 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. ",

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doi = "10.1016/S0002-9149(98)00886-8",

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pages = "453--455",

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T1 - Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

AU - Blackshear, Joseph L.

AU - Zabalgoitia, Miguel

AU - Pennock, Gregory

AU - Fenster, Paul

AU - Strauss, Richard

AU - Halperin, Jonathan

AU - Asinger, Richard

AU - Pearce, Lesly A.

N1 - Funding Information: This study was supported by Grants R01-NS-33551 and R01-NS-24224 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Patients with atrial fibrillation and with documented oartic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

AB - Patients with atrial fibrillation and with documented oartic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

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SN - 0002-9149

VL - 83

SP - 453

EP - 455

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 3

ER -

Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

Abstract

ASJC Scopus subject areas

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