Vitamin D and Liver Disease

R. G. Long, M. R. Wills, Mark R. Haussler, Toni A. Mccain

Research output: Contribution to journalLetterpeer-review


To the Editor: In their review of vitamin D metabolism, Haussler and McCain state that osteomalacia is not normally associated with liver disease and infer that vitamin D metabolism may be unimportant in this situation.1 Bone thinning in liver disease has been recognized for many years,2 and histologic evidence of osteomalacia has been reported in numerous series.3 4 5 6 The observed low serum 25-hydroxyvitamin D (25-OHD) concentrations in patients with chronic liver disease appear to be related more to lack of vitamin D substrate than to a failure of 25-hydroxylation, for serum 25-OHD values usually become normal with vitamin D treatment.78 Reed. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)510-511
Number of pages2
JournalNew England Journal of Medicine
Issue number9
StatePublished - Mar 2 1978

ASJC Scopus subject areas

  • General Medicine


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