Vitamin B6

Vanessa R. Da Silva, Katelyn A. Russell, Jesse F. Gregory

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations


Vitamin B 6 is a family of related compounds comprised of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), along with their phosphate esters and glucosides. The primary vitamin B 6 coenzymic form, pyridoxal 5 '-phosphate, is an obligatory cofactor in over 140 enzymatic reactions primarily in the metabolism of amino acids but also in reactions of carbohydrates and lipids. Vitamin B 6 also plays a vital role in one-carbon metabolism, facilitating cellular methylation processes, methionine recycling, regulation of homocysteine, and synthesis of cysteine. Recent findings indicate that marginal vitamin B 6 status remains a concern in human nutrition, at least in segments of the population. The consequence of marginal vitamin B 6 status is unclear but serves as cause for concern in view of associations between low vitamin B 6 status, risk of cardiovascular disease and stroke, and certain cancers. This chapter provides an overview of vitamin B 6 bioavailability, metabolism and metabolic function, nutritional status and assessment, and roles in human health and disease.

Original languageEnglish (US)
Title of host publicationPresent Knowledge in Nutrition
Subtitle of host publicationTenth Edition
Number of pages14
ISBN (Print)9780470959176
StatePublished - Jun 18 2012


  • Chronic, vitamin B6 nutrition status and aberrant one-carbon metabolism
  • Genetic and nutritional factors in health and disease susceptibility
  • Marginal vitamin B6 status, concerns in human nutrition, of populations
  • PLP metabolism and vitamin B6 deficiency, adverse effects
  • PLP-dependent and one-carbon metabolism, in folate, methionine cycle
  • PLP-dependent, direct/indirect in metabolic phases
  • Vitamin B6 disposition and metabolic function
  • Vitamin B6 metabolism and role as a coenzyme
  • Vitamin B6, a family of related compounds of PN, PL, and PM
  • Vitamin B6, in foods of plant and animal origin

ASJC Scopus subject areas

  • General Medicine


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