Vitamin B12 precursors enhance bioremediation

Research output: Contribution to specialist publicationArticle


University of Arizona researchers found that porphobilinogen (PB), involved in the formation of the corrin ring, increased carbon tetrachloride (CT) biotransformation rates by 2.7-, 8.8- and 10.9-fold when supplemented at 160, 500 and 900 micromoles. A control using 10 micrograms of B12 resulted in a 5.9-fold increase. PB addition resulted in a 57% molar yield of inorganic chloride from CT. The large impact of PB indicates that corrin ring formation is the rate-limiting step of vitamin B12 in methanogens and acetogens found in the environment.

Original languageEnglish (US)
Number of pages2
Specialist publicationIndustrial Bioprocessing
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Chemical Engineering(all)
  • Organic Chemistry


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