Abstract
University of Arizona researchers found that porphobilinogen (PB), involved in the formation of the corrin ring, increased carbon tetrachloride (CT) biotransformation rates by 2.7-, 8.8- and 10.9-fold when supplemented at 160, 500 and 900 micromoles. A control using 10 micrograms of B12 resulted in a 5.9-fold increase. PB addition resulted in a 57% molar yield of inorganic chloride from CT. The large impact of PB indicates that corrin ring formation is the rate-limiting step of vitamin B12 in methanogens and acetogens found in the environment.
| Original language | English (US) |
|---|---|
| Pages | 5-6 |
| Number of pages | 2 |
| Volume | 28 |
| No | 8 |
| Specialist publication | Industrial Bioprocessing |
| State | Published - Aug 2006 |
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- General Chemical Engineering
- Organic Chemistry