University of Arizona researchers found that porphobilinogen (PB), involved in the formation of the corrin ring, increased carbon tetrachloride (CT) biotransformation rates by 2.7-, 8.8- and 10.9-fold when supplemented at 160, 500 and 900 micromoles. A control using 10 micrograms of B12 resulted in a 5.9-fold increase. PB addition resulted in a 57% molar yield of inorganic chloride from CT. The large impact of PB indicates that corrin ring formation is the rate-limiting step of vitamin B12 in methanogens and acetogens found in the environment.
|Original language||English (US)|
|Number of pages||2|
|Specialist publication||Industrial Bioprocessing|
|State||Published - Aug 2006|
ASJC Scopus subject areas
- Chemical Engineering(all)
- Organic Chemistry