Visuospatial perception and navigation in Parkinson's disease

Daniel E. Young; Robert C. Wagenaar; Cheng Chieh Lin; Ying Hui Chou; Sigurros Davidsdottir; Elliot Saltzman; Alice Cronin-Golomb

doi:10.1016/j.visres.2010.08.029

Visuospatial perception and navigation in Parkinson's disease

Daniel E. Young
, Robert C. Wagenaar
, Cheng Chieh Lin
, Ying Hui Chou
, Sigurros Davidsdottir
, Elliot Saltzman
, Alice Cronin-Golomb

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.

Original language	English (US)
Pages (from-to)	2495-2504
Number of pages	10
Journal	Vision Research
Volume	50
Issue number	23
DOIs	https://doi.org/10.1016/j.visres.2010.08.029
State	Published - Nov 23 2010
Externally published	Yes

Keywords

Field of view
Flow
Heading
Optic
Parkinson's disease

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2010.08.029

Cite this

@article{7b314172ffe048debb38b6d100154b2c,

title = "Visuospatial perception and navigation in Parkinson's disease",

abstract = "A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.",

keywords = "Field of view, Flow, Heading, Optic, Parkinson's disease",

author = "Young, \{Daniel E.\} and Wagenaar, \{Robert C.\} and Lin, \{Cheng Chieh\} and Chou, \{Ying Hui\} and Sigurros Davidsdottir and Elliot Saltzman and Alice Cronin-Golomb",

note = "Funding Information: This project was funded by a Grant from the National Institute of Health ( R01 NS050446-01 to A.C.G.) and from a Grant-in-Aid of Research, Sigma Xi (to S.D.). We gratefully thank Erik Giphart from the Steadman-Hawkins Sports Medicine Foundation, Chris Lawlor from the Electronics Design Facility at Boston University, and Tami Rork DeAngelis from the Center for Neurorehabilitation at Boston University for their invaluable support. Our efforts to recruit patients with PD were generously supported by Marie Saint-Hilaire, MD, and Cathi Thomas, RN, MS, of Boston University Medical Center Neurology Associates and by Boston area Parkinson Disease support groups. Most importantly, we thank all of the individuals who participated in this study.",

year = "2010",

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doi = "10.1016/j.visres.2010.08.029",

language = "English (US)",

volume = "50",

pages = "2495--2504",

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AU - Young, Daniel E.

AU - Wagenaar, Robert C.

AU - Lin, Cheng Chieh

AU - Chou, Ying Hui

AU - Davidsdottir, Sigurros

AU - Saltzman, Elliot

AU - Cronin-Golomb, Alice

N1 - Funding Information: This project was funded by a Grant from the National Institute of Health ( R01 NS050446-01 to A.C.G.) and from a Grant-in-Aid of Research, Sigma Xi (to S.D.). We gratefully thank Erik Giphart from the Steadman-Hawkins Sports Medicine Foundation, Chris Lawlor from the Electronics Design Facility at Boston University, and Tami Rork DeAngelis from the Center for Neurorehabilitation at Boston University for their invaluable support. Our efforts to recruit patients with PD were generously supported by Marie Saint-Hilaire, MD, and Cathi Thomas, RN, MS, of Boston University Medical Center Neurology Associates and by Boston area Parkinson Disease support groups. Most importantly, we thank all of the individuals who participated in this study.

PY - 2010/11/23

Y1 - 2010/11/23

N2 - A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.

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KW - Heading

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Visuospatial perception and navigation in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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