TY - JOUR
T1 - Virus-Like Particles Associated with Chloroleukemia in the Rat
AU - Weinstein, Ronald S.
AU - Moloney, William C.
N1 - Funding Information:
This investigation was supported by USPHS Research Grant CA-05691 from Nat. Cancer Inst., and by USPHS Research Grant CA-07368-01 from Nat. Inst. Health.
PY - 1965/2
Y1 - 1965/2
N2 - An electron microscopic study of non-inbred Wistar rats with acute myelogenous leukemia has revealed the presence of intercellular particles with the morphologic features usually ascribed to type C virus particles (9). These particles are approximately 70 mμ in diameter, hexagonal in shape, and may have tail-like structures. Their distribution is similar to that reported for the murine leukemia viruses. Although attempts to isolate leukemogenic viruses from rats with spontaneous leukemia or chemically induced leukemia have been unsuccessful, this study provides morphologic evidence for the existence of such particles in leukemic rats.
AB - An electron microscopic study of non-inbred Wistar rats with acute myelogenous leukemia has revealed the presence of intercellular particles with the morphologic features usually ascribed to type C virus particles (9). These particles are approximately 70 mμ in diameter, hexagonal in shape, and may have tail-like structures. Their distribution is similar to that reported for the murine leukemia viruses. Although attempts to isolate leukemogenic viruses from rats with spontaneous leukemia or chemically induced leukemia have been unsuccessful, this study provides morphologic evidence for the existence of such particles in leukemic rats.
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U2 - 10.3181/00379727-118-29874
DO - 10.3181/00379727-118-29874
M3 - Article
C2 - 14268652
AN - SCOPUS:78651184722
VL - 118
SP - 459
EP - 461
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 0037-9727
IS - 2
ER -