TY - JOUR
T1 - Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways
AU - Lybarger, Lonnie
AU - Wang, Xiaoli
AU - Harris, Michael
AU - Hansen, Ted H.
PY - 2005/2
Y1 - 2005/2
N2 - The CD8 + cytotoxic-T-cell response is a potent mechanism that controls intracellular pathogens, including many viruses. To facilitate transmission, viruses often counter this response by inhibiting the cell surface display of virus-derived peptides on MHC class I molecules. More specifically, recent studies have demonstrated that viruses have evolved remarkable mechanisms to inhibit MHC class I expression by interfering with the function of the MHC class I assembly machinery (the peptide-loading complex) in the endoplasmic reticulum and/or by exploiting endoplasmic-reticulum-associated degradation pathways. These viral molecules are proving invaluable as research tools to illuminate the novel features of physiological pathways that are central to normal cell biology. Furthermore, the detailed characterization of such pathways has yielded significant new insights into host-pathogen interplay.
AB - The CD8 + cytotoxic-T-cell response is a potent mechanism that controls intracellular pathogens, including many viruses. To facilitate transmission, viruses often counter this response by inhibiting the cell surface display of virus-derived peptides on MHC class I molecules. More specifically, recent studies have demonstrated that viruses have evolved remarkable mechanisms to inhibit MHC class I expression by interfering with the function of the MHC class I assembly machinery (the peptide-loading complex) in the endoplasmic reticulum and/or by exploiting endoplasmic-reticulum-associated degradation pathways. These viral molecules are proving invaluable as research tools to illuminate the novel features of physiological pathways that are central to normal cell biology. Furthermore, the detailed characterization of such pathways has yielded significant new insights into host-pathogen interplay.
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U2 - 10.1016/j.coi.2004.11.009
DO - 10.1016/j.coi.2004.11.009
M3 - Review article
C2 - 15653314
AN - SCOPUS:11844257534
SN - 0952-7915
VL - 17
SP - 71
EP - 78
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -