Vestibular Schwannoma Drug Development: Current State-of-the Art

Craig Miller, Holger Sudhoff, Abraham Jacob

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Vestibular schwannomas (VS) can cause significant patient morbidity. Currently, surgery and stereotactic radiation therapy are available treatment options. Recent breakthroughs in research have discovered key cell surface receptors and intracellular signaling pathways that drive vestibular schwannoma tumorigenesis, proliferation, and survival. A number of promising inhibitors targeting these signaling molecules have also now shown efficacy in preclinical VS cell culture models and animal experiments, with some recently entering human clinical trials. In this review, we summarize ErbB receptor signaling, PDGF receptors, MAP kinase signaling, AKT, p21-activated kinase signaling, mTOR, and VEGF signaling in the context of vestibular schwannoma drug development and medical treatment.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalCurrent Otorhinolaryngology Reports
Volume2
Issue number4
DOIs
StatePublished - Dec 2014

Keywords

  • AKT
  • mTOR
  • Neurofibromatosis type II
  • NF2
  • PAK
  • Vestibular schwannomas

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Immunology and Allergy
  • Clinical Neurology

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