Vasopressor therapy for advanced cardiac life support

C. W. Otto

Research output: Contribution to journalReview articlepeer-review


Epinephrine has been the standard vasopressor for use during cardiac arrest since the inception of modern CPR. The effectiveness of epinephrine is due to its ability to increase myocardial oxygen supply by improving coronary blood flow and pressure through peripheral vasoconstriction. Myocardial stimulation through beta-adrenergic receptors is unimportant for resuscitation. Pure alpha-adrenergic agents have been found to have similar success to epinephrine but no better. When used for initial therapy for cardiac arrest, higher doses of epinephrine have not been found to promote better survival than the standard 0.015 mg/kg dose.

Original languageEnglish (US)
Pages (from-to)835-847
Number of pages13
JournalAnesthesiology Clinics of North America
Issue number4
StatePublished - 1995

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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