Vasopressin metabolite, AVP4-9, binding sites in brain: Distribution distinct from that of parent peptide

R. E. Brinton; D. R. Gehlert; J. K. Wamsley; Y. P. Wan; H. I. Yamamura

doi:10.1016/0024-3205(86)90069-X

Vasopressin metabolite, AVP_4-9, binding sites in brain: Distribution distinct from that of parent peptide

R. E. Brinton
, D. R. Gehlert
, J. K. Wamsley
, Y. P. Wan
, H. I. Yamamura

Pharmacology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Binding sites for the vasopressin metabolite peptide, (AVP_4-9), were detected in the rat brain. These binding sites were present in the hilus of the hippocampal formation, superior and inferior colliculus, pontine reticular nuclei, brainstem nuclei, lateral mammillary nucleus, choroid plexus and subfornical organ. The distribution of AVP_4-9 binding sites was distinct from that of the parent peptide (1-3). This distinction was apparent in both the regional and intra-regional distribution.

Original language	English (US)
Pages (from-to)	443-452
Number of pages	10
Journal	Life Sciences
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(86)90069-X
State	Published - Feb 3 1986

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(86)90069-X

Cite this

@article{2ffda1ca31cc4383aa83ec4819c49206,

title = "Vasopressin metabolite, AVP4-9, binding sites in brain: Distribution distinct from that of parent peptide",

abstract = "Binding sites for the vasopressin metabolite peptide, (AVP4-9), were detected in the rat brain. These binding sites were present in the hilus of the hippocampal formation, superior and inferior colliculus, pontine reticular nuclei, brainstem nuclei, lateral mammillary nucleus, choroid plexus and subfornical organ. The distribution of AVP4-9 binding sites was distinct from that of the parent peptide (1-3). This distinction was apparent in both the regional and intra-regional distribution.",

author = "Brinton, \{R. E.\} and Gehlert, \{D. R.\} and Wamsley, \{J. K.\} and Wan, \{Y. P.\} and Yamamura, \{H. I.\}",

note = "Funding Information: This research was supported by a Predoctoral Research Fellowship (MH-08941) awarded to R.E.B. from the National Institutes of Mental Health and by U.S. Public Health Service Grants (\textasciitilde{}-27257 and \textasciitilde{}\{-30636). H.I.Y. is a recipient of a U.S. Public Health Service Research Scientist Development Award, Type (MH-00095), from the National institute of Mental Health.",

year = "1986",

month = feb,

day = "3",

doi = "10.1016/0024-3205(86)90069-X",

language = "English (US)",

volume = "38",

pages = "443--452",

journal = "Life Sciences",

issn = "0024-3205",

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TY - JOUR

T1 - Vasopressin metabolite, AVP4-9, binding sites in brain

T2 - Distribution distinct from that of parent peptide

AU - Brinton, R. E.

AU - Gehlert, D. R.

AU - Wamsley, J. K.

AU - Wan, Y. P.

AU - Yamamura, H. I.

N1 - Funding Information: This research was supported by a Predoctoral Research Fellowship (MH-08941) awarded to R.E.B. from the National Institutes of Mental Health and by U.S. Public Health Service Grants (~-27257 and ~{-30636). H.I.Y. is a recipient of a U.S. Public Health Service Research Scientist Development Award, Type (MH-00095), from the National institute of Mental Health.

PY - 1986/2/3

Y1 - 1986/2/3

N2 - Binding sites for the vasopressin metabolite peptide, (AVP4-9), were detected in the rat brain. These binding sites were present in the hilus of the hippocampal formation, superior and inferior colliculus, pontine reticular nuclei, brainstem nuclei, lateral mammillary nucleus, choroid plexus and subfornical organ. The distribution of AVP4-9 binding sites was distinct from that of the parent peptide (1-3). This distinction was apparent in both the regional and intra-regional distribution.

AB - Binding sites for the vasopressin metabolite peptide, (AVP4-9), were detected in the rat brain. These binding sites were present in the hilus of the hippocampal formation, superior and inferior colliculus, pontine reticular nuclei, brainstem nuclei, lateral mammillary nucleus, choroid plexus and subfornical organ. The distribution of AVP4-9 binding sites was distinct from that of the parent peptide (1-3). This distinction was apparent in both the regional and intra-regional distribution.

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UR - https://www.scopus.com/pages/publications/0022560037#tab=citedBy

U2 - 10.1016/0024-3205(86)90069-X

DO - 10.1016/0024-3205(86)90069-X

M3 - Article

C2 - 3945171

AN - SCOPUS:0022560037

SN - 0024-3205

VL - 38

SP - 443

EP - 452

JO - Life Sciences

JF - Life Sciences

IS - 5

ER -

Vasopressin metabolite, AVP_4-9, binding sites in brain: Distribution distinct from that of parent peptide

Abstract

ASJC Scopus subject areas

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