Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development

Q. Chen, S. S. Schreiber, R. D. Brinton

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We investigated the developmental expression of vasopressin and oxytocin receptor and peptide mRNA using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot hybridization. Messenger RNAs for both vasopressin receptor subtypes V1a and V2 were present in the telencephalon from embryonic day 12 to day 20. Both V1a and V2 receptor mRNA increased on day 13 and then remained stable from embryonic day 13 to day 20. Messenger RNA for the vasopressin peptide was also detected in the telencephalon from day 12 to day 20, indicating that vasopressin could be synthesized within the rat cerebral cortex during rat embryonic development. Oxytocin receptor mRNA expression was also present in the telencephalon, but expression levels varied considerably from day 12 to day 20. No oxytocin mRNA expression was detected during rat telencephalon development. Temporal patterns of vasopressin receptor and vasopressin peptide mRNA expression along with oxytocin receptor mRNA suggest a temporal role for vasopressin- and oxytocin-mediated actions during rat telencephalon development. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalNeuropeptides
Volume34
Issue number3-4
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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