Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract

R. P. Zimmerman; T. S. Gates; C. R. Mantyh; S. R. Vigna; C. G. Boehmer; P. W. Mantyh

doi:10.1016/0196-9781(88)90188-X

Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract

R. P. Zimmerman, T. S. Gates, C. R. Mantyh, S. R. Vigna, C. G. Boehmer, P. W. Mantyh

Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of ¹²⁵I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.

Original language	English (US)
Pages (from-to)	1241-1253
Number of pages	13
Journal	Peptides
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(88)90188-X
State	Published - 1988

Keywords

Autoradiography
Canine gastrointestinal tract
Receptors
VIP
Vasoactive intestinal peptide

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(88)90188-X

Cite this

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title = "Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract",

abstract = "Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.",

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author = "Zimmerman, {R. P.} and Gates, {T. S.} and Mantyh, {C. R.} and Vigna, {S. R.} and Boehmer, {C. G.} and Mantyh, {P. W.}",

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AU - Zimmerman, R. P.

AU - Gates, T. S.

AU - Mantyh, C. R.

AU - Vigna, S. R.

AU - Boehmer, C. G.

AU - Mantyh, P. W.

PY - 1988

Y1 - 1988

N2 - Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.

AB - Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.

KW - Autoradiography

KW - Canine gastrointestinal tract

KW - Receptors

KW - VIP

KW - Vasoactive intestinal peptide

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Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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