Vascular Dysfunction in Polycystic Kidney Disease: A Mini-Review

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Polycystic kidney disease (PKD) is one of the most common hereditary kidney diseases, which is characterized by progressive cyst growth and secondary hypertension. In addition to cystogenesis and renal abnormalities, patients with PKD can develop vascular abnormalities and cardiovascular complications. Progressive cyst growth substantially alters renal structure and culminates into end-stage renal disease. There remains no cure beyond renal transplantation, and treatment options remain largely limited to chronic renal replacement therapy. In addition to end-stage renal disease, patients with PKD also present with hypertension and cardiovascular disease, yet the timing and interactions between the cardiovascular and renal effects of PKD progression are understudied. Here, we review the vascular dysfunction found in clinical and preclinical models of PKD, including the clinical manifestations and relationship to hypertension, stroke, and related cardiovascular diseases. Finally, our discussion also highlights the critical questions and emerging areas in vascular research in PKD.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalJournal of Vascular Research
Volume60
Issue number3
DOIs
StatePublished - Sep 1 2023

Keywords

  • Autosomal dominant polycystic kidney disease
  • Autosomal recessive polycystic kidney disease
  • End stage renal disease
  • Fibrocystin
  • Hypertension
  • Polycystic kidney disease
  • Polycystin
  • Vascular dysfunction
  • Wire myography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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