TY - JOUR
T1 - Varicella-zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapy
AU - Weinberg, Adriana
AU - Wiznia, Andrew A.
AU - LaFleur, Bonnie J.
AU - Shah, Sona
AU - Levin, Myron J.
N1 - Funding Information:
Received 2 December 2003; accepted 28 January 2004; electronically published 9 June 2004. Financial support: National Institute of Child Health and Human Development (contract NO1-HD-3-3162). Reprints or correspondence: Dr. Adriana Weinberg, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Campus Box C227, Denver, CO 80262 ([email protected]).
PY - 2004/7/15
Y1 - 2004/7/15
N2 - Herpes zoster (HZ) is a frequent complication of advanced human immunodeficiency virus (HIV) infection. We determined the effect of highly active antiretroviral therapy (HAART) on reconstitution of varicella-zoster virus (VZV)-specific cell-mediated immunity (VZV-CMI) in 56 VZV- and HIV-infected children. VZV-CMI did not change over the course of ≥3 years of observation, despite a reduction in HIV load. VZV-CMI correlated with lower HIV load but not with CD4 cell percentage. The incidence of HZ was unaffected by HAART. None of 5 patients who developed HZ during the study had VZV-CMI before developing HZ. After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication.
AB - Herpes zoster (HZ) is a frequent complication of advanced human immunodeficiency virus (HIV) infection. We determined the effect of highly active antiretroviral therapy (HAART) on reconstitution of varicella-zoster virus (VZV)-specific cell-mediated immunity (VZV-CMI) in 56 VZV- and HIV-infected children. VZV-CMI did not change over the course of ≥3 years of observation, despite a reduction in HIV load. VZV-CMI correlated with lower HIV load but not with CD4 cell percentage. The incidence of HZ was unaffected by HAART. None of 5 patients who developed HZ during the study had VZV-CMI before developing HZ. After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication.
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U2 - 10.1086/422011
DO - 10.1086/422011
M3 - Article
C2 - 15216460
AN - SCOPUS:3242705597
SN - 0022-1899
VL - 190
SP - 267
EP - 270
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -