TY - JOUR
T1 - Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States
T2 - The Severe ARDS: Generating Evidence Study
AU - the Severe ARDS: Generating Evidence (SAGE) Study Investigators
AU - the Society of Critical Care Medicine's Discovery Network
AU - Qadir, Nida
AU - Bartz, Raquel R.
AU - Cooter, Mary L.
AU - Hough, Catherine L.
AU - Lanspa, Michael J.
AU - Banner-Goodspeed, Valerie M.
AU - Chen, Jen Ting
AU - Giovanni, Shewit
AU - Gomaa, Dina
AU - Sjoding, Michael W.
AU - Hajizadeh, Negin
AU - Komisarow, Jordan
AU - Duggal, Abhijit
AU - Khanna, Ashish K.
AU - Kashyap, Rahul
AU - Khan, Akram
AU - Chang, Steven Y.
AU - Tonna, Joseph E.
AU - Anderson, Harry L.
AU - Liebler, Janice M.
AU - Mosier, Jarrod M.
AU - Morris, Peter E.
AU - Genthon, Alissa
AU - Louh, Irene K.
AU - Tidswell, Mark
AU - Stephens, R. Scott
AU - Esper, Annette M.
AU - Dries, David J.
AU - Martinez, Anthony
AU - Schreyer, Kraftin E.
AU - Bender, William
AU - Tiwari, Anupama
AU - Guru, Pramod K.
AU - Hanna, Sinan
AU - Gong, Michelle N.
AU - Park, Pauline K.
AU - Steingrub, Jay S.
AU - Brierley, Kristin
AU - Larson, Julia L.
AU - Mueller, Ariel
AU - Pinkhasova, Tereza
AU - Talmor, Daniel
AU - Aisiku, Imoigele
AU - Baron, Rebecca
AU - Fredenburgh, Lauren
AU - Hou, Peter
AU - Massaro, Anthony
AU - Seethala, Raghu
AU - Hite, Duncan
AU - Brodie, Daniel
N1 - Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Background: Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown. Research Question: What is the impact of treatment variability on mortality in patients with moderate to severe ARDS in the United States? Study Design and Methods: We conducted a multicenter, observational cohort study of mechanically ventilated adults with ARDS and PaO2 to FIO2 ratio of ≤ 150 with positive end-expiratory pressure of ≥ 5 cm H2O, who were admitted to 29 US centers between October 1, 2016, and April 30, 2017. The primary outcome was 28-day in-hospital mortality. Center variation in ventilator management, adjunctive therapy use, and mortality also were assessed. Results: A total of 2,466 patients were enrolled. Median baseline PaO2 to FIO2 ratio was 105 (interquartile range, 78.0-129.0). In-hospital 28-day mortality was 40.7%. Initial adherence to lung protective ventilation (LPV; tidal volume, ≤ 6.5 mL/kg predicted body weight; plateau pressure, or when unavailable, peak inspiratory pressure, ≤ 30 mm H2O) was 31.4% and varied between centers (0%-65%), as did rates of adjunctive therapy use (27.1%-96.4%), methods used (neuromuscular blockade, prone positioning, systemic steroids, pulmonary vasodilators, and extracorporeal support), and mortality (16.7%-73.3%). Center standardized mortality ratios (SMRs), calculated using baseline patient-level characteristics to derive expected mortality rate, ranged from 0.33 to 1.98. Of the treatment-level factors explored, only center adherence to early LPV was correlated with SMR. Interpretation: Substantial center-to-center variability exists in ARDS management, suggesting that further opportunities for improving ARDS outcomes exist. Early adherence to LPV was associated with lower center mortality and may be a surrogate for overall quality of care processes. Future collaboration is needed to identify additional treatment-level factors influencing center-level outcomes. Trial Registry: ClinicalTrials.gov; No.: NCT03021824; URL: www.clinicaltrials.gov
AB - Background: Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown. Research Question: What is the impact of treatment variability on mortality in patients with moderate to severe ARDS in the United States? Study Design and Methods: We conducted a multicenter, observational cohort study of mechanically ventilated adults with ARDS and PaO2 to FIO2 ratio of ≤ 150 with positive end-expiratory pressure of ≥ 5 cm H2O, who were admitted to 29 US centers between October 1, 2016, and April 30, 2017. The primary outcome was 28-day in-hospital mortality. Center variation in ventilator management, adjunctive therapy use, and mortality also were assessed. Results: A total of 2,466 patients were enrolled. Median baseline PaO2 to FIO2 ratio was 105 (interquartile range, 78.0-129.0). In-hospital 28-day mortality was 40.7%. Initial adherence to lung protective ventilation (LPV; tidal volume, ≤ 6.5 mL/kg predicted body weight; plateau pressure, or when unavailable, peak inspiratory pressure, ≤ 30 mm H2O) was 31.4% and varied between centers (0%-65%), as did rates of adjunctive therapy use (27.1%-96.4%), methods used (neuromuscular blockade, prone positioning, systemic steroids, pulmonary vasodilators, and extracorporeal support), and mortality (16.7%-73.3%). Center standardized mortality ratios (SMRs), calculated using baseline patient-level characteristics to derive expected mortality rate, ranged from 0.33 to 1.98. Of the treatment-level factors explored, only center adherence to early LPV was correlated with SMR. Interpretation: Substantial center-to-center variability exists in ARDS management, suggesting that further opportunities for improving ARDS outcomes exist. Early adherence to LPV was associated with lower center mortality and may be a surrogate for overall quality of care processes. Future collaboration is needed to identify additional treatment-level factors influencing center-level outcomes. Trial Registry: ClinicalTrials.gov; No.: NCT03021824; URL: www.clinicaltrials.gov
KW - ARDS
KW - corticosteroids
KW - extracorporeal membrane oxygenation
KW - mechanical ventilation
KW - neuromuscular blockade
KW - prone positioning
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U2 - 10.1016/j.chest.2021.05.047
DO - 10.1016/j.chest.2021.05.047
M3 - Article
C2 - 34089739
AN - SCOPUS:85113617641
SN - 0012-3692
VL - 160
SP - 1304
EP - 1315
JO - CHEST
JF - CHEST
IS - 4
ER -