Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

Rajan Kochar; Moises I. Nevah; Frank J. Lukens; Michael B. Fallon; Victor I. Machicao

doi:10.3748/wjg.v16.i26.3335

Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

Rajan Kochar, Moises I. Nevah, Frank J. Lukens, Michael B. Fallon, Victor I. Machicao

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance of intrahepatic bile ducts. Multiple etiologies have been indentified including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome.

Original language	English (US)
Pages (from-to)	3335-3338
Number of pages	4
Journal	World Journal of Gastroenterology
Volume	16
Issue number	26
DOIs	https://doi.org/10.3748/wjg.v16.i26.3335
State	Published - Jul 14 2010
Externally published	Yes

Keywords

Acquired immune deficiency syndrome
Cholangiopathy
Cholestasis
Drug-induced liver injury
Ductopenia
Vanishing bile duct syndrome

ASJC Scopus subject areas

Gastroenterology

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10.3748/wjg.v16.i26.3335

Cite this

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abstract = "Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance of intrahepatic bile ducts. Multiple etiologies have been indentified including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome.",

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AU - Kochar, Rajan

AU - Nevah, Moises I.

AU - Lukens, Frank J.

AU - Fallon, Michael B.

AU - Machicao, Victor I.

PY - 2010/7/14

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KW - Acquired immune deficiency syndrome

KW - Cholangiopathy

KW - Cholestasis

KW - Drug-induced liver injury

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Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

Abstract

Keywords

ASJC Scopus subject areas

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