Vagus nerve stimulation therapy for epilepsy in older adults

Joseph I. Sirven, M. Sperling, D. Naritoku, S. Schachter, D. Labar, M. Holmes, A. Wilensky, J. Cibula, D. M. Labiner, D. Bergen, R. Ristanovic, J. Harvey, R. Dasheiff, G. L. Morris, C. A. O'Donovan, L. Ojemann, D. Scales, M. Nadkarni, B. Richards, J. D. Sanchez

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The authors assessed the efficacy, safety, and tolerability of vagus nerve stimulation (VNS) for refractory epilepsy in 45 adults 50 years of age and older. They determined seizure frequency, adverse effects, and quality of life. At 3 months, 12 patients had a >50% decrease in seizure frequency; at 1 year, 21 of 31 studied individuals had a >50% seizure decrease. Side effects were mild and transient. Quality of life scores improved significantly with time.

Original languageEnglish (US)
Pages (from-to)1179-1182
Number of pages4
Issue number5
StatePublished - Mar 14 2000


  • Epilepsy
  • Seizures
  • Vagus nerve stimulation-Elderly

ASJC Scopus subject areas

  • Clinical Neurology


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