Uvaretin, a New Antitumor Agent from Uvaria acuminata (Annonaceae)

Jack R. Cole; Sterling J. Torrance; Richard M. Wiedhopf; Satish K. Arora; Robert B. Bates

doi:10.1021/jo00872a037

Uvaretin, a New Antitumor Agent from Uvaria acuminata (Annonaceae)

Jack R. Cole, Sterling J. Torrance, Richard M. Wiedhopf, Satish K. Arora, Robert B. Bates

Pharmacy Practice and Science

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Abstract

The chloroform extract of Uvaria acuminata Oliv. has shown inhibitory activity against the P-388 lymphocytic leukemia test system of the National Cancer Institute. The major constituent of this extract was identified as the new 3′-benzyldihydrochalcone uvaretin, 1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenyl-lpropanone (C₂₃H₂₂O₅)· The structure was proven by x-ray crystallography and other methods.

Original language	English (US)
Pages (from-to)	1852-1855
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	41
Issue number	10
DOIs	https://doi.org/10.1021/jo00872a037
State	Published - May 1 1976

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Organic Chemistry

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abstract = "The chloroform extract of Uvaria acuminata Oliv. has shown inhibitory activity against the P-388 lymphocytic leukemia test system of the National Cancer Institute. The major constituent of this extract was identified as the new 3′-benzyldihydrochalcone uvaretin, 1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenyl-lpropanone (C23H22O5)· The structure was proven by x-ray crystallography and other methods.",

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AU - Torrance, Sterling J.

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AU - Arora, Satish K.

AU - Bates, Robert B.

PY - 1976/5/1

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AB - The chloroform extract of Uvaria acuminata Oliv. has shown inhibitory activity against the P-388 lymphocytic leukemia test system of the National Cancer Institute. The major constituent of this extract was identified as the new 3′-benzyldihydrochalcone uvaretin, 1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenyl-lpropanone (C23H22O5)· The structure was proven by x-ray crystallography and other methods.

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Uvaretin, a New Antitumor Agent from Uvaria acuminata (Annonaceae)

Abstract

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