Abstract
Background and Objectives: Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods: OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results: Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference (P < 0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences (P < 0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion: OCT has the potential to guide biopsies and provide non-invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials.
Original language | English (US) |
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Pages (from-to) | 687-695 |
Number of pages | 9 |
Journal | Lasers in Surgery and Medicine |
Volume | 39 |
Issue number | 9 |
DOIs | |
State | Published - Oct 2007 |
Keywords
- Actinic keratosis
- Image processing
- Imaging
- Skin cancer
ASJC Scopus subject areas
- Surgery
- Dermatology