Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

Michal E. Komlosh; Dan Benjamini; Elizabeth B. Hutchinson; Sarah King; Margalit Haber; Alexandru V. Avram; Lynne A. Holtzclaw; Abhishek Desai; Carlo Pierpaoli; Peter J. Basser

doi:10.1016/j.micromeso.2017.05.030

Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

Michal E. Komlosh
, Dan Benjamini
, Elizabeth B. Hutchinson
, Sarah King
, Margalit Haber
, Alexandru V. Avram
, Lynne A. Holtzclaw
, Abhishek Desai
, Carlo Pierpaoli
, Peter J. Basser

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Double pulsed-field gradient (dPFG) MRI is proposed as a new sensitive tool to detect and characterize tissue microstructure following diffuse axonal injury. In this study dPFG MRI was used to estimate apparent mean axon diameter in a diffuse axonal injury animal model and in healthy fixed mouse brain. Histological analysis was used to verify the presence of the injury detected by MRI.

Original language	English (US)
Pages (from-to)	156-159
Number of pages	4
Journal	Microporous and Mesoporous Materials
Volume	269
DOIs	https://doi.org/10.1016/j.micromeso.2017.05.030
State	Published - Oct 2018
Externally published	Yes

Keywords

Anisotropic diffusion
CHIMERA
DAI
DDE
DTI
Diffusion
MRI
Microstructure
TBI
d-PFG

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials

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10.1016/j.micromeso.2017.05.030

Cite this

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title = "Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)",

abstract = "Double pulsed-field gradient (dPFG) MRI is proposed as a new sensitive tool to detect and characterize tissue microstructure following diffuse axonal injury. In this study dPFG MRI was used to estimate apparent mean axon diameter in a diffuse axonal injury animal model and in healthy fixed mouse brain. Histological analysis was used to verify the presence of the injury detected by MRI.",

keywords = "Anisotropic diffusion, CHIMERA, DAI, DDE, DTI, Diffusion, MRI, Microstructure, TBI, d-PFG",

author = "Komlosh, \{Michal E.\} and Dan Benjamini and Hutchinson, \{Elizabeth B.\} and Sarah King and Margalit Haber and Avram, \{Alexandru V.\} and Holtzclaw, \{Lynne A.\} and Abhishek Desai and Carlo Pierpaoli and Basser, \{Peter J.\}",

note = "Funding Information: This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development [grant numbers HD000266 ] and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , [HJF Award Numbers: 308049-8.01-60855 and 307513-3.01-60855 ]. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = oct,

doi = "10.1016/j.micromeso.2017.05.030",

language = "English (US)",

volume = "269",

pages = "156--159",

journal = "Microporous and Mesoporous Materials",

issn = "1387-1811",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

AU - Komlosh, Michal E.

AU - Benjamini, Dan

AU - Hutchinson, Elizabeth B.

AU - King, Sarah

AU - Haber, Margalit

AU - Avram, Alexandru V.

AU - Holtzclaw, Lynne A.

AU - Desai, Abhishek

AU - Pierpaoli, Carlo

AU - Basser, Peter J.

N1 - Funding Information: This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development [grant numbers HD000266 ] and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc , [HJF Award Numbers: 308049-8.01-60855 and 307513-3.01-60855 ]. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2018/10

Y1 - 2018/10

N2 - Double pulsed-field gradient (dPFG) MRI is proposed as a new sensitive tool to detect and characterize tissue microstructure following diffuse axonal injury. In this study dPFG MRI was used to estimate apparent mean axon diameter in a diffuse axonal injury animal model and in healthy fixed mouse brain. Histological analysis was used to verify the presence of the injury detected by MRI.

AB - Double pulsed-field gradient (dPFG) MRI is proposed as a new sensitive tool to detect and characterize tissue microstructure following diffuse axonal injury. In this study dPFG MRI was used to estimate apparent mean axon diameter in a diffuse axonal injury animal model and in healthy fixed mouse brain. Histological analysis was used to verify the presence of the injury detected by MRI.

KW - Anisotropic diffusion

KW - CHIMERA

KW - DAI

KW - DDE

KW - DTI

KW - Diffusion

KW - MRI

KW - Microstructure

KW - TBI

KW - d-PFG

UR - https://www.scopus.com/pages/publications/85020180878

UR - https://www.scopus.com/pages/publications/85020180878#tab=citedBy

U2 - 10.1016/j.micromeso.2017.05.030

DO - 10.1016/j.micromeso.2017.05.030

M3 - Article

AN - SCOPUS:85020180878

SN - 1387-1811

VL - 269

SP - 156

EP - 159

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

ER -

Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

Abstract

Keywords

ASJC Scopus subject areas

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