Use of the QOLIE-31 in routine clinical practice

Amy Nicole Grudzinski, Zafar Hakim, Stephen Joel Coons, David M. Labiner

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The most important outcome of medical care may be the patient's perception of his or her functioning and well-being, or quality of life. However, patient-reported quality of life is not often routinely and/or adequately assessed. This study examined the usefulness of health-related quality of life (HRQoL) information in predicting patient-reported health status when compared with information routinely obtained in a physician- patient interaction. A survey instrument was administered to 40 patients immediately prior to a scheduled epilepsy clinic visit. The instrument included the 31-item Quality of Life in Epilepsy inventory (QOLIE-31) and 21 additional items that assessed, among other things, information routinely obtained in a physician-patient interaction regarding adverse drug effects and seizure frequency. Regression analysis revealed that information regarding seizure frequency and adverse drug effects provided little insight into patients' self-perceived health status. Only 11.25% of the variance in patients' self-reported health status was explained by variations in these traditional measures. The addition of QOLIE-derived data to traditional information significantly improved the ability to predict patients' self- reported health status. The results of this study indicate that the administration of an HRQoL instrument in routine clinical practice offers additional insight into patients' serf-perceived health status. Furthermore, the study indicated that this additional information can be collected in a reasonable amount of time.

Original languageEnglish (US)
Pages (from-to)34-47
Number of pages14
JournalJournal of Epilepsy
Issue number1
StatePublished - Jan 1998


  • Epilepsy
  • Health-related quality of life
  • Quality of life in epilepsy inventory
  • Routine clinical practice.

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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