TY - JOUR
T1 - Use of antidepressants and statins and short-term risk of new-onset diabetes among high risk adults
AU - Bhattacharya, Rituparna
AU - Ajmera, Mayank
AU - Bhattacharjee, Sandipan
AU - Sambamoorthi, Usha
PY - 2014/8
Y1 - 2014/8
N2 - Aims: We evaluated the association of combined use of antidepressants and statins and the risk of new-onset diabetes among high-risk adults. Methods: We used a retrospective, observational, longitudinal design among adults (age ≥22 years) who were diabetes free at baseline and had reported hypertension or hyperlipidemia or heart disease. We used data were from 2004 to 2009 Medical Expenditure Panel Survey and identified from self-reported diabetes or insulin use. We categorized antidepressants and statins use into four groups: antidepressants only, statins only, combined use of antidepressants and statins (antidepressants-statins), and neither antidepressant nor statins. We conducted chi-square and multivariable logistic regressions to examine the association between use of antidepressants-statins and new-onset diabetes after controlling for demographic and economic characteristics, health-status, access to care, presence of depression, and lifestyle risk factors. Results: In our study sample, 9.3% used antidepressants only, 10.7% used statins only and 2.4% adults reported use of antidepressants-statins. Nearly 2% of the study sample reported new-onset diabetes. In unadjusted analyses, significantly higher proportion of adults using antidepressants-statins (3.2%) reported new-onset diabetes compared to those using neither antidepressants nor statins (1.1%). However, after controlling for all other variables in multivariable regression we did not observe a statistically significant association between use of antidepressants-statins and new-onset diabetes. Conclusions: Our study results do not suggest that use of antidepressants-statins may increase the risk of new-onset diabetes. Future research needs to examine this relationship with specific combinations of these drug classes and using longer follow up periods.
AB - Aims: We evaluated the association of combined use of antidepressants and statins and the risk of new-onset diabetes among high-risk adults. Methods: We used a retrospective, observational, longitudinal design among adults (age ≥22 years) who were diabetes free at baseline and had reported hypertension or hyperlipidemia or heart disease. We used data were from 2004 to 2009 Medical Expenditure Panel Survey and identified from self-reported diabetes or insulin use. We categorized antidepressants and statins use into four groups: antidepressants only, statins only, combined use of antidepressants and statins (antidepressants-statins), and neither antidepressant nor statins. We conducted chi-square and multivariable logistic regressions to examine the association between use of antidepressants-statins and new-onset diabetes after controlling for demographic and economic characteristics, health-status, access to care, presence of depression, and lifestyle risk factors. Results: In our study sample, 9.3% used antidepressants only, 10.7% used statins only and 2.4% adults reported use of antidepressants-statins. Nearly 2% of the study sample reported new-onset diabetes. In unadjusted analyses, significantly higher proportion of adults using antidepressants-statins (3.2%) reported new-onset diabetes compared to those using neither antidepressants nor statins (1.1%). However, after controlling for all other variables in multivariable regression we did not observe a statistically significant association between use of antidepressants-statins and new-onset diabetes. Conclusions: Our study results do not suggest that use of antidepressants-statins may increase the risk of new-onset diabetes. Future research needs to examine this relationship with specific combinations of these drug classes and using longer follow up periods.
KW - Antidepressants
KW - New-onset diabetes
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=84906043374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906043374&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2014.04.016
DO - 10.1016/j.diabres.2014.04.016
M3 - Article
C2 - 24954100
AN - SCOPUS:84906043374
SN - 0168-8227
VL - 105
SP - 251
EP - 260
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 2
ER -