The five-year review reported herein tends to confirm other reports indicating that nosusceptibility patterns can be regarded as permanent, and that susceptibility testing of the isolated pathogens is necessary in each case of resistant urinary tract infection. On the other hand, it appears that the belief in the pattern stability of the chemical urinary agents may not be entirely erroneous. Antibacterial agents such as nitrofurantoin have shown a relatively stable pattern of effectiveness and clinical safety over a number of years. They continue to have an important role in the treatment of nonobstructive urinary tract disease.
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