Carcinoembryonic antigen (CEA) determinations were done on 109 urine samples from 24 patients with bladder cancer. Analysis of the results allows several tentative conclusions. Urine samples obtained from bladders with active cancer had higher urine CEA levels than bladders with no tumors present. Higher stage lesions had higher urine CEA levels but there was no correlation with grade. The greater the mass and surface area, the greater the urine CEA level. Infected urine had a higher CEA level than sterile urine but the difference was less than the difference in urine CEA levels between bladders with and without cancer. Urine CEA is a potentially valuable test in the diagnosis of urothelial cancer but more investigation is warranted before it can be used clinically.
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