Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal; Joshua Miller; James M. Mathew; Sunil Kurian; Anat R. Tambur; John Friedewald; Jane Charrette; Michael M. Abecassis

doi:10.1016/j.humimm.2018.01.010

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal
, Joshua Miller
, James M. Mathew
, Sunil Kurian
, Anat R. Tambur
, John Friedewald
, Jane Charrette
, Michael M. Abecassis

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4⁺CD25^HighCD127⁻FOXP3⁺) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

Original language	English (US)
Pages (from-to)	277-282
Number of pages	6
Journal	Human Immunology
Volume	79
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2018.01.010
State	Published - May 2018
Externally published	Yes

Keywords

Genomic markers
HLA-identical renal transplants
T and B regulatory cells
Tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2018.01.010

Cite this

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title = "Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells",

abstract = "Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.",

keywords = "Genomic markers, HLA-identical renal transplants, T and B regulatory cells, Tolerance",

author = "Leventhal, \{Joseph R.\} and Joshua Miller and Mathew, \{James M.\} and Sunil Kurian and Tambur, \{Anat R.\} and John Friedewald and Jane Charrette and Abecassis, \{Michael M.\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Society for Histocompatibility and Immunogenetics",

year = "2018",

month = may,

doi = "10.1016/j.humimm.2018.01.010",

language = "English (US)",

volume = "79",

pages = "277--282",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

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T1 - Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

AU - Leventhal, Joseph R.

AU - Miller, Joshua

AU - Mathew, James M.

AU - Kurian, Sunil

AU - Tambur, Anat R.

AU - Friedewald, John

AU - Charrette, Jane

AU - Abecassis, Michael M.

PY - 2018/5

Y1 - 2018/5

N2 - Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

AB - Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

KW - Genomic markers

KW - HLA-identical renal transplants

KW - T and B regulatory cells

KW - Tolerance

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UR - https://www.scopus.com/pages/publications/85041659565#tab=citedBy

U2 - 10.1016/j.humimm.2018.01.010

DO - 10.1016/j.humimm.2018.01.010

M3 - Review article

C2 - 29408689

AN - SCOPUS:85041659565

SN - 0198-8859

VL - 79

SP - 277

EP - 282

JO - Human Immunology

JF - Human Immunology

IS - 5

ER -

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Abstract

Keywords

ASJC Scopus subject areas

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