Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal, Joshua Miller, James M. Mathew, Sunil Kurian, Anat R. Tambur, John Friedewald, Jane Charrette, Michael M. Abecassis

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalHuman Immunology
Volume79
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • Genomic markers
  • HLA-identical renal transplants
  • T and B regulatory cells
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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