Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal; Joshua Miller; James M. Mathew; Sunil Kurian; Anat R. Tambur; John Friedewald; Jane Charrette; Michael M. Abecassis

doi:10.1016/j.humimm.2018.01.010

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal, Joshua Miller, James M. Mathew, Sunil Kurian, Anat R. Tambur, John Friedewald, Jane Charrette, Michael M. Abecassis

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4⁺CD25^HighCD127⁻FOXP3⁺) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

Original language	English (US)
Pages (from-to)	277-282
Number of pages	6
Journal	Human Immunology
Volume	79
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2018.01.010
State	Published - May 2018
Externally published	Yes

Keywords

Genomic markers
HLA-identical renal transplants
T and B regulatory cells
Tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2018.01.010

Cite this

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title = "Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells",

abstract = "Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.",

keywords = "Genomic markers, HLA-identical renal transplants, T and B regulatory cells, Tolerance",

author = "Leventhal, {Joseph R.} and Joshua Miller and Mathew, {James M.} and Sunil Kurian and Tambur, {Anat R.} and John Friedewald and Jane Charrette and Abecassis, {Michael M.}",

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doi = "10.1016/j.humimm.2018.01.010",

language = "English (US)",

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AU - Leventhal, Joseph R.

AU - Miller, Joshua

AU - Mathew, James M.

AU - Kurian, Sunil

AU - Tambur, Anat R.

AU - Friedewald, John

AU - Charrette, Jane

AU - Abecassis, Michael M.

PY - 2018/5

Y1 - 2018/5

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AB - Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

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KW - HLA-identical renal transplants

KW - T and B regulatory cells

KW - Tolerance

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Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Abstract

Keywords

ASJC Scopus subject areas

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