Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Tom V. Adamkiewicz; Paul Szabolcs; Ann Haight; K. Scott Baker; Susan Staba; Amos Kedar; K. Y. Chiang; Lakshmanan Krishnamurti; Michael W. Boyer; Joan Kurtzberg; John E. Wagner; John R. Wingard; Andrew M. Yeager

doi:10.1111/j.1399-3046.2007.00725.x

Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Tom V. Adamkiewicz
, Paul Szabolcs
, Ann Haight
, K. Scott Baker
, Susan Staba
, Amos Kedar
, K. Y. Chiang
, Lakshmanan Krishnamurti
, Michael W. Boyer
, Joan Kurtzberg
, John E. Wagner
, John R. Wingard
, Andrew M. Yeager

Cancer Center Division

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

Original language	English (US)
Pages (from-to)	641-644
Number of pages	4
Journal	Pediatric transplantation
Volume	11
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-3046.2007.00725.x
State	Published - Sep 2007

Keywords

Reduced intensity conditioning
Sickle cell disease
Umbilical cord transplant
Unrelated donor transplant

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/j.1399-3046.2007.00725.x

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Adamkiewicz, T. V., Szabolcs, P., Haight, A., Baker, K. S., Staba, S., Kedar, A., Chiang, K. Y., Krishnamurti, L., Boyer, M. W., Kurtzberg, J., Wagner, J. E., Wingard, J. R., & Yeager, A. M. (2007). Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience. Pediatric transplantation, 11(6), 641-644. https://doi.org/10.1111/j.1399-3046.2007.00725.x

Adamkiewicz, TV, Szabolcs, P, Haight, A, Baker, KS, Staba, S, Kedar, A, Chiang, KY, Krishnamurti, L, Boyer, MW, Kurtzberg, J, Wagner, JE, Wingard, JR & Yeager, AM 2007, 'Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience', Pediatric transplantation, vol. 11, no. 6, pp. 641-644. https://doi.org/10.1111/j.1399-3046.2007.00725.x

@article{9414f97540a2484692b94195446151d4,

title = "Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience",

abstract = "UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57\%) developed viral infections. Engraftment, GVHD, and infection remain challenges.",

keywords = "Reduced intensity conditioning, Sickle cell disease, Umbilical cord transplant, Unrelated donor transplant",

author = "Adamkiewicz, \{Tom V.\} and Paul Szabolcs and Ann Haight and Baker, \{K. Scott\} and Susan Staba and Amos Kedar and Chiang, \{K. Y.\} and Lakshmanan Krishnamurti and Boyer, \{Michael W.\} and Joan Kurtzberg and Wagner, \{John E.\} and Wingard, \{John R.\} and Yeager, \{Andrew M.\}",

year = "2007",

month = sep,

doi = "10.1111/j.1399-3046.2007.00725.x",

language = "English (US)",

volume = "11",

pages = "641--644",

journal = "Pediatric transplantation",

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AU - Adamkiewicz, Tom V.

AU - Szabolcs, Paul

AU - Haight, Ann

AU - Baker, K. Scott

AU - Staba, Susan

AU - Kedar, Amos

AU - Chiang, K. Y.

AU - Krishnamurti, Lakshmanan

AU - Boyer, Michael W.

AU - Kurtzberg, Joan

AU - Wagner, John E.

AU - Wingard, John R.

AU - Yeager, Andrew M.

PY - 2007/9

Y1 - 2007/9

N2 - UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

AB - UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

KW - Reduced intensity conditioning

KW - Sickle cell disease

KW - Umbilical cord transplant

KW - Unrelated donor transplant

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SN - 1397-3142

VL - 11

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JO - Pediatric transplantation

JF - Pediatric transplantation

IS - 6

ER -

Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Abstract

Keywords

ASJC Scopus subject areas

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