Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Tom V. Adamkiewicz; Paul Szabolcs; Ann Haight; K. Scott Baker; Susan Staba; Amos Kedar; K. Y. Chiang; Lakshmanan Krishnamurti; Michael W. Boyer; Joan Kurtzberg; John E. Wagner; John R. Wingard; Andrew M. Yeager

doi:10.1111/j.1399-3046.2007.00725.x

Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Tom V. Adamkiewicz
, Paul Szabolcs
, Ann Haight
, K. Scott Baker
, Susan Staba
, Amos Kedar
, K. Y. Chiang
, Lakshmanan Krishnamurti
, Michael W. Boyer
, Joan Kurtzberg
, John E. Wagner
, John R. Wingard
, Andrew M. Yeager

Cancer Center

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

Original language	English (US)
Pages (from-to)	641-644
Number of pages	4
Journal	Pediatric transplantation
Volume	11
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-3046.2007.00725.x
State	Published - Sep 2007

Keywords

Reduced intensity conditioning
Sickle cell disease
Umbilical cord transplant
Unrelated donor transplant

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/j.1399-3046.2007.00725.x

Cite this

Adamkiewicz, T. V., Szabolcs, P., Haight, A., Baker, K. S., Staba, S., Kedar, A., Chiang, K. Y., Krishnamurti, L., Boyer, M. W., Kurtzberg, J., Wagner, J. E., Wingard, J. R., & Yeager, A. M. (2007). Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience. Pediatric transplantation, 11(6), 641-644. https://doi.org/10.1111/j.1399-3046.2007.00725.x

Adamkiewicz, TV, Szabolcs, P, Haight, A, Baker, KS, Staba, S, Kedar, A, Chiang, KY, Krishnamurti, L, Boyer, MW, Kurtzberg, J, Wagner, JE, Wingard, JR & Yeager, AM 2007, 'Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience', Pediatric transplantation, vol. 11, no. 6, pp. 641-644. https://doi.org/10.1111/j.1399-3046.2007.00725.x

@article{9414f97540a2484692b94195446151d4,

title = "Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience",

abstract = "UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57\%) developed viral infections. Engraftment, GVHD, and infection remain challenges.",

keywords = "Reduced intensity conditioning, Sickle cell disease, Umbilical cord transplant, Unrelated donor transplant",

author = "Adamkiewicz, \{Tom V.\} and Paul Szabolcs and Ann Haight and Baker, \{K. Scott\} and Susan Staba and Amos Kedar and Chiang, \{K. Y.\} and Lakshmanan Krishnamurti and Boyer, \{Michael W.\} and Joan Kurtzberg and Wagner, \{John E.\} and Wingard, \{John R.\} and Yeager, \{Andrew M.\}",

year = "2007",

month = sep,

doi = "10.1111/j.1399-3046.2007.00725.x",

language = "English (US)",

volume = "11",

pages = "641--644",

journal = "Pediatric transplantation",

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T2 - Review of four-center experience

AU - Adamkiewicz, Tom V.

AU - Szabolcs, Paul

AU - Haight, Ann

AU - Baker, K. Scott

AU - Staba, Susan

AU - Kedar, Amos

AU - Chiang, K. Y.

AU - Krishnamurti, Lakshmanan

AU - Boyer, Michael W.

AU - Kurtzberg, Joan

AU - Wagner, John E.

AU - Wingard, John R.

AU - Yeager, Andrew M.

PY - 2007/9

Y1 - 2007/9

N2 - UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

AB - UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

KW - Reduced intensity conditioning

KW - Sickle cell disease

KW - Umbilical cord transplant

KW - Unrelated donor transplant

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SN - 1397-3142

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JO - Pediatric transplantation

JF - Pediatric transplantation

IS - 6

ER -

Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

Abstract

Keywords

ASJC Scopus subject areas

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