TY - JOUR
T1 - University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy
T2 - A prospective, multicenter study
AU - Maoz, Sabrina L.
AU - Golzar, Autreen
AU - Choby, Garret
AU - Hwang, Peter H.
AU - Wang, Eric W.
AU - Kuan, Edward C.
AU - Adappa, Nithin D.
AU - Geltzeiler, Mathew
AU - Getz, Anne E.
AU - Humphreys, Ian M.
AU - Le, Christopher H.
AU - Pinheiro-Neto, Carlos D.
AU - Fischer, Jakob L.
AU - Chan, Erik P.
AU - Abuzeid, Waleed M.
AU - Chang, Eugene H.
AU - Jafari, Aria
AU - Kingdom, Todd T.
AU - Kohanski, Michael A.
AU - Lee, Jivianne K.
AU - Lazor, Jillian W.
AU - Nabavizadeh, Ali
AU - Nayak, Jayakar V.
AU - Palmer, James N.
AU - Patel, Zara M.
AU - Resnick, Adam C.
AU - Smith, Timothy L.
AU - Snyderman, Carl H.
AU - St. John, Maie A.
AU - Storm, Phillip B.
AU - Suh, Jeffrey D.
AU - Wang, Marilene B.
AU - Sim, Myung S.
AU - Beswick, Daniel M.
N1 - Publisher Copyright:
© 2024 The Author(s). International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
PY - 2024
Y1 - 2024
N2 - Purpose: Sinonasal malignancies (SNMs) adversely impact patients’ quality of life (QOL) and are frequently identified at an advanced stage. Because these tumors are rare, there are few studies that examine the specific QOL areas that are impacted. This knowledge would help improve the care of these patients. Methods: In this prospective, multi-institutional study, 273 patients with SNMs who underwent definitive treatment with curative intent were evaluated. We used the University of Washington Quality of Life (UWQOL) instrument over 5 years from diagnosis to identify demographic, treatment, and disease-related factors that influence each of the 12 UWQOL subdomains from baseline to 5 -years post-treatment. Results: Multivariate models found endoscopic resection predicted improved pain (vs. nonsurgical treatment CI 2.4, 19.4, p = 0.01) and appearance versus open (CI 27.0, 35.0, p < 0.001) or combined (CI 10.4, 17.1, p < 0.001). Pterygopalatine fossa involvement predicted worse swallow (CI −10.8, −2.4, p = 0.01) and pain (CI −17.0, −4.0, p < 0.001). Neck dissection predicted worse swallow (CI −14.8, −2.8, p < 0.001), taste (CI −31.7, −1.5, p = 0.02), and salivary symptoms (CI −28.4, −8.6, p < 0.001). Maxillary involvement predicted worse chewing (CI 9.8, 33.2; p < 0.001) and speech (CI −21.8, −5.4, p < 0.001) relative to other sites. Advanced T stage predicted worse anxiety (CI −13.0, −2.0, p = 0.03). Conclusions: Surgical approach, management of cervical disease, tumor extent, and site of involvement impacted variable UWQOL symptom areas. Endoscopic resection predicted better pain, appearance, and chewing compared with open. These results may aid in counseling patients regarding potential QOL expectations in their SNM treatment and recovery course.
AB - Purpose: Sinonasal malignancies (SNMs) adversely impact patients’ quality of life (QOL) and are frequently identified at an advanced stage. Because these tumors are rare, there are few studies that examine the specific QOL areas that are impacted. This knowledge would help improve the care of these patients. Methods: In this prospective, multi-institutional study, 273 patients with SNMs who underwent definitive treatment with curative intent were evaluated. We used the University of Washington Quality of Life (UWQOL) instrument over 5 years from diagnosis to identify demographic, treatment, and disease-related factors that influence each of the 12 UWQOL subdomains from baseline to 5 -years post-treatment. Results: Multivariate models found endoscopic resection predicted improved pain (vs. nonsurgical treatment CI 2.4, 19.4, p = 0.01) and appearance versus open (CI 27.0, 35.0, p < 0.001) or combined (CI 10.4, 17.1, p < 0.001). Pterygopalatine fossa involvement predicted worse swallow (CI −10.8, −2.4, p = 0.01) and pain (CI −17.0, −4.0, p < 0.001). Neck dissection predicted worse swallow (CI −14.8, −2.8, p < 0.001), taste (CI −31.7, −1.5, p = 0.02), and salivary symptoms (CI −28.4, −8.6, p < 0.001). Maxillary involvement predicted worse chewing (CI 9.8, 33.2; p < 0.001) and speech (CI −21.8, −5.4, p < 0.001) relative to other sites. Advanced T stage predicted worse anxiety (CI −13.0, −2.0, p = 0.03). Conclusions: Surgical approach, management of cervical disease, tumor extent, and site of involvement impacted variable UWQOL symptom areas. Endoscopic resection predicted better pain, appearance, and chewing compared with open. These results may aid in counseling patients regarding potential QOL expectations in their SNM treatment and recovery course.
KW - endoscopic sinus surgery
KW - paranasal sinus diseases
KW - patient reported outcome measure
KW - postoperative
KW - quality of life
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U2 - 10.1002/alr.23386
DO - 10.1002/alr.23386
M3 - Article
AN - SCOPUS:85196023427
SN - 2042-6976
JO - International Forum of Allergy and Rhinology
JF - International Forum of Allergy and Rhinology
ER -