University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study

Sabrina L. Maoz, Autreen Golzar, Garret Choby, Peter H. Hwang, Eric W. Wang, Edward C. Kuan, Nithin D. Adappa, Mathew Geltzeiler, Anne E. Getz, Ian M. Humphreys, Christopher H. Le, Carlos D. Pinheiro-Neto, Jakob L. Fischer, Erik P. Chan, Waleed M. Abuzeid, Eugene H. Chang, Aria Jafari, Todd T. Kingdom, Michael A. Kohanski, Jivianne K. LeeJillian W. Lazor, Ali Nabavizadeh, Jayakar V. Nayak, James N. Palmer, Zara M. Patel, Adam C. Resnick, Timothy L. Smith, Carl H. Snyderman, Maie A. St. John, Phillip B. Storm, Jeffrey D. Suh, Marilene B. Wang, Myung S. Sim, Daniel M. Beswick

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: Sinonasal malignancies (SNMs) adversely impact patients’ quality of life (QOL) and are frequently identified at an advanced stage. Because these tumors are rare, there are few studies that examine the specific QOL areas that are impacted. This knowledge would help improve the care of these patients. Methods: In this prospective, multi-institutional study, 273 patients with SNMs who underwent definitive treatment with curative intent were evaluated. We used the University of Washington Quality of Life (UWQOL) instrument over 5 years from diagnosis to identify demographic, treatment, and disease-related factors that influence each of the 12 UWQOL subdomains from baseline to 5 -years post-treatment. Results: Multivariate models found endoscopic resection predicted improved pain (vs. nonsurgical treatment CI 2.4, 19.4, p = 0.01) and appearance versus open (CI 27.0, 35.0, p < 0.001) or combined (CI 10.4, 17.1, p < 0.001). Pterygopalatine fossa involvement predicted worse swallow (CI −10.8, −2.4, p = 0.01) and pain (CI −17.0, −4.0, p < 0.001). Neck dissection predicted worse swallow (CI −14.8, −2.8, p < 0.001), taste (CI −31.7, −1.5, p = 0.02), and salivary symptoms (CI −28.4, −8.6, p < 0.001). Maxillary involvement predicted worse chewing (CI 9.8, 33.2; p < 0.001) and speech (CI −21.8, −5.4, p < 0.001) relative to other sites. Advanced T stage predicted worse anxiety (CI −13.0, −2.0, p = 0.03). Conclusions: Surgical approach, management of cervical disease, tumor extent, and site of involvement impacted variable UWQOL symptom areas. Endoscopic resection predicted better pain, appearance, and chewing compared with open. These results may aid in counseling patients regarding potential QOL expectations in their SNM treatment and recovery course.

Original languageEnglish (US)
JournalInternational Forum of Allergy and Rhinology
DOIs
StateAccepted/In press - 2024

Keywords

  • endoscopic sinus surgery
  • paranasal sinus diseases
  • patient reported outcome measure
  • postoperative
  • quality of life

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'University of Washington Quality of Life subdomain outcomes after treatment of sinonasal malignancy: A prospective, multicenter study'. Together they form a unique fingerprint.

Cite this