TY - JOUR
T1 - Uniparental Markers in Italy Reveal a Sex-Biased Genetic Structure and Different Historical Strata
AU - the Genographic Consortium
AU - Boattini, Alessio
AU - Martinez-Cruz, Begona
AU - Sarno, Stefania
AU - Harmant, Christine
AU - Useli, Antonella
AU - Sanz, Paula
AU - Yang-Yao, Daniele
AU - Manry, Jeremy
AU - Ciani, Graziella
AU - Luiselli, Donata
AU - Quintana-Murci, Lluis
AU - Comas, David
AU - Pettener, Davide
AU - Adhikarla, Syama
AU - Adler, Christina J.
AU - Balanovska, Elena
AU - Balanovsky, Oleg
AU - Bertranpetit, Jaume
AU - Clarke, Andrew C.
AU - Cooper, Alan
AU - Der Sarkissian, Clio S.I.D.
AU - Dulik, Matthew C.
AU - Gaieski, Jill B.
AU - Kumar, Arun
AU - Prasad, Ganesh
AU - Haak, Wolfgang
AU - Haber, Marc
AU - Jin, Li
AU - Kaplan, Matthew E.
AU - Li, Hui
AU - Li, Shilin
AU - Matisoo-Smith, Elizabeth A.
AU - Merchant, Nirav C.
AU - Mitchell, R. John
AU - Owings, Amanda C.
AU - Parida, Laxmi
AU - Pitchappan, Ramasamy
AU - Platt, Daniel E.
AU - Renfrew, Colin
AU - Lacerda, Daniela R.
AU - Royyuru, Ajay K.
AU - Santos, Fabrıcio R.
AU - Schurr, Theodore G.
AU - Soodyall, Himla
AU - Hernanz, David F.Soria
AU - Swamikrishnan, Pandikumar
AU - Tyler-Smith, Chris
AU - Santhakumari, Arun Varatharajan
AU - Vieira, Pedro Paulo
AU - Vilar, Miguel G.
PY - 2013/5/29
Y1 - 2013/5/29
N2 - Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in ∼900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West-South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe.
AB - Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in ∼900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West-South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe.
UR - https://www.scopus.com/pages/publications/84878454396
UR - https://www.scopus.com/pages/publications/84878454396#tab=citedBy
U2 - 10.1371/journal.pone.0065441
DO - 10.1371/journal.pone.0065441
M3 - Article
C2 - 23734255
AN - SCOPUS:84878454396
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 5
M1 - e65441
ER -