Unilateral sporadic retinoblastoma presenting as acute secondary glaucoma with intraocular inflammation

We describe a case of unilateral sporadic retinoblastoma presenting as intraocular inflammation and secondary acute glaucoma in a six-year-old boy. Fine-needle aspiration biopsy (FNAB) of the anterior chamber was needed to confirm the diagnosis as both B-scan ultrasonography and computerized tomography (CT) revealed no intraocular mass or calcifications. Enucleation was performed. Histopathology showed a diffuse infiltrating retinoblastoma with involvement of the trabecular meshwork and Schlemm's canal. Because of the extensive duration of symptoms, the identification of tumor cells in Schlemm's canal/collector channels indicating possible extraocular extension, the patient received prophylactic chemotherapy. The patient has had no recurrence 24 months following treatment.