Understanding neuroinflammation through central nervous system infections

Hannah J. Johnson, Anita A. Koshy

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Neuroinflammation is now recognized to compound many central nervous system (CNS) pathologies, from stroke to dementia. As immune responses evolved to handle infections, studying CNS infections can offer unique insights into the CNS immune response and address questions such as: What defenses and strategies do CNS parenchymal cells deploy in response to a dangerous pathogen? How do CNS cells interact with each other and infiltrating immune cells to control microbes? What pathways are beneficial for the host or for the pathogen? Here, we review recent studies that use CNS-tropic infections in combination with cutting-edge techniques to delve into the complex relationships between microbes, immune cells, and cells of the CNS.

Original languageEnglish (US)
Article number102619
JournalCurrent Opinion in Neurobiology
StatePublished - Oct 2022

ASJC Scopus subject areas

  • General Neuroscience


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