TY - JOUR
T1 - Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients
AU - Fiuza-Luces, Carmen
AU - Garatachea, Nuria
AU - Simpson, Richard J.
AU - Berger, Nathan A.
AU - Ramírez, Manuel
AU - Lucia, Alejandro
N1 - Funding Information:
Fiuza-Luces C. is supported by a Sara Borrell contract (file number CD14/00005) from the Institute of Health Carlos III (ISCIII), the main Public Research Entity funding, managing and carrying out biomedical research in Spain. The ISCIII reports directly to the Ministry of Economy and Competitiveness and in operational terms to both this Ministry and to the Ministry of Health, Social Services and Equality.
Publisher Copyright:
© 2002 by Hinnak Northoff.
PY - 2015
Y1 - 2015
N2 - Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD.
AB - Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD.
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M3 - Review article
C2 - 25826127
AN - SCOPUS:84928698682
VL - 21
SP - 80
EP - 112
JO - Exercise Immunology Review
JF - Exercise Immunology Review
SN - 1077-5552
ER -