Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients

Carmen Fiuza-Luces, Nuria Garatachea, Richard J. Simpson, Nathan A. Berger, Manuel Ramírez, Alejandro Lucia

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD.

Original languageEnglish (US)
Pages (from-to)80-112
Number of pages33
JournalExercise Immunology Review
Volume21
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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