Abstract
Models of natural action selection implicate fronto-striatal circuits in both motor and cognitive 'actions'. Dysfunction of these circuits leads to decision-making deficits in various populations. We review how computational models provide insights into the mechanistic basis for these deficits in Parkinson's patients and those with ventromedial frontal damage. We then consider implications of the models for understanding behaviour and cognition in attention-deficit/hyperactivity disorder (ADHD). Incorporation of cortical noradrenaline function into the model improves action selection in noisy environments and accounts for response variability in ADHD. We close with more general clinical implications.
Original language | English (US) |
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Pages (from-to) | 1641-1654 |
Number of pages | 14 |
Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
Volume | 362 |
Issue number | 1485 |
DOIs | |
State | Published - Sep 29 2007 |
Keywords
- Action selection
- Basal ganglia
- Computational models
- Decision making
- Neurological disorders
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences